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Results for "

lectin-like oxidized LDL receptor-1

" in MedChemExpress (MCE) Product Catalog:

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Inhibitors & Agonists

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Recombinant Proteins

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Antibodies

Cat. No. Compare Product Name Species Source
  • HY-P71180
    OLR1 Protein, Human (HEK293, His)

    oxidized Low-Density Lipoprotein receptor 1; Ox-LDL receptor 1; C-Type lectin Domain Family 8 Member A; lectin-like oxidized LDL receptor 1; LOX-1; lectin-like oxLDL receptor 1; hLOX-1; lectin-Type oxidized LDL receptor 1; OLR1; CLEC8A; LOX1

    		Human HEK293
    OLR1 Protein, a receptor on vascular endothelial cells, plays a key role in recognizing, internalizing, and degrading oxidatively modified low-density lipoprotein (oxLDL). As a marker of atherosclerosis, oxLDL induces vascular endothelial cell activation, leading to pro-inflammatory responses, oxidative conditions, and apoptosis. OLR1's association with oxLDL activates NF-kappa-B, contributing to pro-atherogenic responses such as reduced nitric oxide release, monocyte adhesion, and apoptosis. Beyond oxLDL, it serves as a receptor for HSP70, participating in cell-mediated antigen cross-presentation and functioning as a leukocyte-adhesion molecule in inflammation. Additionally, OLR1 recognizes AGE products, activated platelets, monocytes, apoptotic cells, and bacteria. OLR1 Protein, Human (HEK293, His) is the recombinant human-derived OLR1 protein, expressed by HEK293, with C-6*His labeled tag. The total length of OLR1 Protein, Human (HEK293, His) is 213 a.a., with molecular weight of 30-35 kDa.

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